Opportunity Information: Apply for RFA HL 19 009
The Cardiothoracic Surgical Trials Network (CTSN) Linked Clinical Research Centers (LCRCs) opportunity (RFA-HL-19-009) is a National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement (UM1) that supports institutions willing to serve as participating clinical research sites within the CTSN. The overall purpose is to strengthen a national, coordinated infrastructure for running high-quality, multi-center research in cardiothoracic surgery, with an emphasis on studies that matter not only to surgeons but also to broader cardiovascular and neurologic care. Although it uses the UM1 cooperative agreement mechanism, the notice is labeled "Clinical Trial Not Allowed," meaning applicants are not proposing and launching their own independent clinical trial under this specific award; instead, they are applying to be part of a network structure that will conduct network-developed trials and related studies in collaboration with NHLBI.
At its core, the program is built around the idea that complex heart surgery care increasingly depends on cross-specialty, team-based approaches that span surgery, cardiology, anesthesiology, critical care, and neurology. LCRCs are expected to conduct collaborative randomized controlled trials and other rigorous studies that evaluate interventions, strategies of care, and novel therapies in the context of cardiac surgery, while producing findings that can influence practice beyond a single specialty. The intent is for evidence generated in surgical settings to translate into improvements in real-world outcomes and inform clinical decision-making that benefits a broad patient population, including groups with high disease burden.
A notable feature of the opportunity is its explicit inclusion of implementation research running alongside randomized trials. In addition to helping execute the trials themselves, LCRCs are expected to contribute to research that examines how best to achieve uptake, fidelity, and long-term sustainability of evidence-based practices once results are available. This focuses attention on the practical barriers that often prevent proven interventions from being adopted widely, such as workflow constraints, team coordination challenges, variable local resources, and differences in patient populations. By pairing implementation work with clinical effectiveness research, the network aims to shorten the time from discovery to routine care, especially in settings where cardiovascular disease burden is high.
Another major objective is workforce development. The FOA emphasizes fostering the next generation of clinical and implementation researchers, which typically implies that participating centers should create an environment that supports mentorship, hands-on involvement in multi-center trials, and career development opportunities for early-stage investigators and trainees. In practice, that often means building site-level capabilities not just for enrolling participants, but for maintaining strong regulatory compliance, data quality, recruitment and retention strategies, and collaboration across disciplines and institutions.
From an administrative standpoint, this is a discretionary funding opportunity under the Health activity category, offered by the U.S. Department of Health and Human Services through NIH/NHLBI. It is associated with CFDA numbers 93.837 and 93.840. The cooperative agreement structure indicates substantial scientific and/or programmatic involvement by NHLBI compared with a standard grant, consistent with network trials that require centralized coordination, common protocols, shared data systems, and harmonized operating procedures across sites.
Eligibility is broad and includes many types of domestic organizations that can support clinical research operations. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions in those categories); for-profit organizations (other than small businesses); small businesses; and other organizations as described in the FOA’s additional eligibility language. This breadth reflects the reality that clinical trial infrastructure may reside in academic medical centers, integrated health systems, research institutes, and other organizations capable of conducting regulated human subjects research.
Funding details provided for the opportunity include an award ceiling of $400,000 and an expected number of awards of five. The FOA was created on May 16, 2018, with an original closing date of August 2, 2018. In summary, the opportunity is designed to expand and strengthen the CTSN by adding Linked Clinical Research Centers that can reliably execute multi-center cardiothoracic surgical studies, contribute to implementation research that improves real-world adoption of findings, and help train the research workforce needed to sustain and advance evidence-based surgical and cardiovascular care.Apply for RFA HL 19 009
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Cardiothoracic Surgical Trials Network (CTSN) Linked Clinical Research Centers (UM1 Clinical Trial Not Allowed )" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837, 93.840.
- This funding opportunity was created on May 16, 2018.
- Applicants must submit their applications by Aug 02, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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