Opportunity Information: Apply for RFA RM 18 020
This funding opportunity, titled "Limited Competition: Human Heredity and Health in Africa Consortium Biorepository (U24 Clinical Trial Not Allowed)" (RFA-RM-18-020), is a National Institutes of Health (NIH) cooperative agreement aimed at strengthening the biorepository backbone of the Human Heredity and Health in Africa (H3Africa) initiative. The core goal is to fund efforts that further develop and sustain up to three H3Africa Biorepositories by building on infrastructure that already exists, rather than creating entirely new repositories from scratch. Because it uses a U24 cooperative agreement mechanism, the award is structured as a partnership with NIH involvement in key aspects of oversight and coordination, and it explicitly does not support clinical trials under this announcement.
The funded biorepositories are expected to operate as high-capacity, state-of-the-art facilities that can reliably support H3Africa research across the continent. A central responsibility is maintaining modern methods and technologies for DNA-related workflows, including biospecimen collection approaches, processing pipelines, quality control systems, handling procedures, data-linked management practices, and long-term storage. In practical terms, this means applicants are expected to show they can preserve specimen integrity and traceability from receipt through storage and eventual distribution, while applying rigorous quality standards that make the samples dependable for genomic and other biomedical analyses. The FOA also allows repositories to propose collection and handling for additional specimen types beyond DNA, including (but not limited to) PBMCs (peripheral blood mononuclear cells), plasma, and serum, reflecting the broader needs of genomic, immunologic, and biomarker research.
A major emphasis of the opportunity is service and stewardship. These biorepositories are not just storage sites; they are support hubs meant to provide the operational services needed for biospecimen collection and dissemination in Africa. That includes enabling standardized collection across multiple studies and sites, ensuring consistent processing methods, and distributing biospecimens in a controlled way to qualified researchers. Just as important, the FOA highlights responsible stewardship of specimens that are linked to well-curated phenotypic and genomic data, meaning the repository function must be aligned with strong data management practices, careful documentation, and governance processes that protect participant interests while still enabling scientific use.
Coordination requirements are explicit and central to the program. The biorepositories must work closely with active H3Africa research projects to ensure that collection priorities, sample handling requirements, and distribution plans match real research demand. They must also coordinate with the H3Africa Bioinformatics Network (H3ABioNet), which underscores that the biospecimens are expected to be meaningfully connected to robust datasets. The intent is an integrated system in which high-quality biological samples and high-quality, well-structured data reinforce each other, improving reproducibility, downstream analysis, and overall research value.
From an administrative standpoint, the opportunity is offered by the U.S. Department of Health and Human Services through NIH, falls under a health funding activity category, and is listed under CFDA 93.310. The opportunity was created on June 27, 2018, with an original closing date of October 3, 2018. The award ceiling is listed as $1,000,000, with an anticipated total of three awards, which matches the goal of supporting "up to three" biorepositories. Eligibility is broad and includes various government entities, tribal governments and organizations, public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, and small businesses, with additional eligibility details referenced in the full announcement.
Overall, the FOA is designed to keep a limited number of high-performing African biorepositories operational, modernized, and tightly connected to the wider H3Africa ecosystem. The emphasis is on sustainable infrastructure, high technical standards for specimen processing and storage, reliable service to research teams, and coordinated governance so that biospecimens and associated phenotypic and genomic information can be shared responsibly and used effectively to advance genomics and health research in Africa.Apply for RFA RM 18 020
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Human Heredity and Health in Africa Consortium Biorepository (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Jun 27, 2018.
- Applicants must submit their applications by Oct 03, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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