Opportunity Information: Apply for PAR 22 046
The NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22) (Funding Opportunity Number PAR-22-046) is an NIH career transition grant designed specifically for highly qualified dentists who are currently in NIH intramural postdoctoral fellowship positions. Its core goal is to help these intramural fellows move from a mentored, training-focused research environment inside the NIH to an independent research position at an extramural institution, with dedicated support intended to launch them as new investigators who can compete for and sustain independent research funding. In practical terms, the program is meant to bridge a common career gap: leaving the structured mentorship of the NIH Intramural Research Program and establishing an independent, externally funded lab or research program at a university, research institute, or other eligible organization outside NIH.
This opportunity is categorized as a discretionary grant program under the NIH (Agency: National Institutes of Health), within the health funding activity area, and is associated with CFDA number 93.121. The “K22” mechanism signals that it is a career development-to-independence transition award rather than a traditional research project grant. The specific version here is labeled “Basic Experimental Studies Involving Humans Required,” which indicates that the intended research scope must include human subjects work that fits NIH’s definition of basic experimental studies involving humans. Applicants interested in this FOA should interpret that label as more than a clerical tag: it affects how the application must address human subjects protections, study design, and NIH policy expectations for this category of human research.
Eligibility on the applicant organization side is broad and includes many U.S.-based organizational types that commonly host NIH-funded investigators. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations both with and without 501(c)(3) IRS status (when not institutions of higher education); public housing authorities/Indian housing authorities; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized tribal governments. The FOA also explicitly notes additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. It also allows for-profit organizations (other than small businesses) and small businesses as eligible applicant organizations, which can be relevant when a dentist-scientist is transitioning into certain research institute or industry-adjacent environments, assuming all other NIH and FOA requirements are met.
At the same time, there are clear limits related to non-U.S. entities. Non-domestic (non-U.S.) entities (foreign organizations or foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, the FOA states that foreign components, as defined in the NIH Grants Policy Statement, are allowed. That means the primary applicant institution must be eligible and based in the U.S. (or an eligible U.S. territory/possession entity), but certain parts of the project can involve foreign collaboration or performance sites if they meet NIH’s definition and are well-justified under NIH policy.
From an administrative standpoint, the opportunity was created on 2022-01-10, and the original closing date listed is 2024-07-18. The funding instrument type is a grant. The source data provided does not specify an award ceiling or the expected number of awards, which usually means applicants would need to consult the full FOA text and NIH budget guidance to understand typical NIDCR K22 budget limits, allowable costs, and how NIDCR expects the transition and independent phases to be supported.
Overall, this K22 is best understood as a structured on-ramp for dentist-scientists who have already demonstrated strong promise during NIH intramural postdoctoral training and are ready to step into an extramural faculty-equivalent or independent investigator role. The emphasis is not just on completing another mentored project, but on building a credible, fundable independent research trajectory in dental, oral, and craniofacial research, with required involvement of basic experimental studies in humans and with institutional eligibility rules that keep the applicant organization domestic while still permitting appropriately defined foreign components.Apply for PAR 22 046
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Basic Experimental Studies Involving Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on 2022-01-10.
- Applicants must submit their applications by 2024-07-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22) - PAR-22-046
What is the NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22)?
It is an NIH career transition grant from the National Institute of Dental and Craniofacial Research (NIDCR) designed for highly qualified dentists who are currently NIH intramural postdoctoral fellows. It is intended to support their move from an NIH intramural, mentored training environment to an independent research position at an extramural institution.
What is the main purpose of this K22 opportunity?
The core goal is to bridge the career gap between mentored intramural research training at NIH and establishing an independent, externally funded research program at an eligible organization outside NIH. The award is meant to help launch recipients as new investigators who can compete for and sustain independent research funding.
Who is this program specifically designed for?
This K22 is designed specifically for dentists who are in NIH intramural postdoctoral fellowship positions and who are ready to transition to an independent extramural research role.
What does the K22 mechanism indicate about the type of award?
The K22 mechanism indicates a career development-to-independence transition award. It is not a traditional research project grant; instead, it supports a structured transition toward independence as an investigator.
What is the Funding Opportunity Number (FOA) for this program?
The Funding Opportunity Number is PAR-22-046.
Which NIH institute is associated with this funding opportunity?
The opportunity is associated with NIDCR (the National Institute of Dental and Craniofacial Research) within the National Institutes of Health (NIH).
How is this opportunity categorized in terms of funding type and activity area?
It is described as a discretionary grant program under NIH, in the health funding activity area, using a grant funding instrument.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.121.
What does the label "Basic Experimental Studies Involving Humans Required" mean for applicants?
This label indicates that the intended research scope must include human subjects work that fits NIH's definition of basic experimental studies involving humans. It is not just an administrative tag; it affects how the application addresses human subjects protections, study design, and NIH policy expectations for this category of human research.
Does this FOA require human subjects research?
Yes. The opportunity is labeled "Basic Experimental Studies Involving Humans Required," meaning the project is expected to include human subjects research that meets NIH's definition for this category.
Why does the human research label matter for how an application is written?
Because the label signals specific NIH expectations, applicants need to address human subjects protections, the study design, and other relevant NIH policies in a way that aligns with "basic experimental studies involving humans."
Where is the award intended to help recipients transition to?
The program is meant to support transition to an independent research position at an extramural institution, such as a university, research institute, or other eligible organization outside NIH.
What types of U.S. organizations are eligible to apply as the applicant organization?
Eligible applicant organizations include a wide range of U.S.-based entities commonly hosting NIH-funded investigators, including state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and nonprofit organizations (with or without 501(c)(3) IRS status, when not institutions of higher education).
Are tribal governments and tribal organizations eligible applicant organizations?
Yes. Federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments are listed as eligible applicant organizations.
Are public housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are included among the eligible applicant organizations.
Are institutions that serve specific populations explicitly included as eligible?
Yes. The FOA explicitly notes categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and TCCUs, among others.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed among the additional eligible categories.
Are regional organizations eligible to apply?
Yes. Regional organizations are included among the eligible categories.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are listed among the eligible applicant organization categories.
Are U.S. territories or possessions included as eligible applicant organizations?
Yes. U.S. territories or possessions are listed as eligible.
Can for-profit organizations apply as the applicant organization?
Yes. For-profit organizations (other than small businesses) are listed as eligible applicant organizations, and small businesses are also listed as eligible.
Are foreign (non-U.S.) organizations eligible to apply as the applicant organization?
No. Non-domestic (non-U.S.) entities, such as foreign organizations or foreign institutions, are not eligible to apply as the applicant organization.
Can a non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization.
Are foreign components allowed at all under this FOA?
Yes. The FOA states that foreign components, as defined in the NIH Grants Policy Statement, are allowed. This means the primary applicant institution must be eligible and domestic, but certain project elements may involve foreign collaboration or performance sites if they meet NIH's definition and are appropriately justified.
What does it mean that foreign components are allowed but foreign organizations cannot apply?
It means the main applicant organization must be a qualifying U.S.-based entity (or an eligible U.S. territory/possession entity), while specific aspects of the work may occur outside the U.S. if they qualify as an NIH-defined foreign component and are justified under NIH policy.
When was this funding opportunity created?
The opportunity was created on 2022-01-10.
What is the listed closing date for this opportunity?
The original closing date listed is 2024-07-18.
What is the funding instrument type for this opportunity?
The funding instrument type is a grant.
Does the provided information specify an award ceiling or the expected number of awards?
No. The source information provided does not specify an award ceiling or the expected number of awards.
What does it imply if award ceilings and number of awards are not specified in the provided summary?
Based on the provided information, it suggests applicants would typically need to consult the full FOA text and NIH budget guidance to understand typical budget limits, allowable costs, and how support is structured.
What kind of career stage is this K22 meant to support?
It is meant for dentist-scientists who have demonstrated strong promise during NIH intramural postdoctoral training and are prepared to step into a faculty-equivalent or independent investigator role in an extramural setting.
What research field focus is implied by NIDCR and the program description?
The program is described as supporting an independent research trajectory in dental, oral, and craniofacial research.
Is the emphasis of this award on continued mentorship or on independence?
The emphasis is on establishing a credible, fundable independent research trajectory, rather than simply completing another mentored research project.
In practical terms, what gap does this program aim to address?
It aims to address the gap that often occurs when an NIH intramural fellow leaves a structured mentorship environment and must establish an independent, externally funded lab or research program at an institution outside NIH.
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